Desonide ointment 0.05% is a prescription low-potency topical corticosteroid commonly used to treat mild to moderate eczema. It helps reduce redness, itching, and inflammation during flares and is especially useful on sensitive areas like the face, neck, skin folds, and in children when used as directed.

Although stronger than hydrocortisone 1%, as a weaker steroid, desonide is generally safer for short-term or intermittent use, but it should still be applied in a thin layer and not used continuously for long periods. Regular moisturizing alongside desonide improves control and helps prevent future flares.