Studies show they can modestly improve short-term outcomes—such as faster skin healing, less acute pain, and better sleep or activity levels—when used with antiviral therapy. They may be considered as adjunctive treatment in immunocompetent adults with severe pain or functional impairment, but only if there are no contraindications like uncontrolled diabetes or hypertension. A common regimen is prednisone 60 mg daily, tapered over 10–14 days alongside antivirals. Corticosteroids should not be used alone or in immunocompromised patients. Corticosteroids do not reduce the risk or duration of postherpetic neuralgia in patients with herpes zoster.

Overall, their role is limited and must be carefully weighed against potential risks.