Herpes Zoster

Skin

Shingles

Herpes zoster (shingles) is caused by reactivation of the varicella-zoster virus, which remains dormant in nerve roots after childhood chickenpox. It presents as a painful, blistering rash limited to one side of the body, following a dermatomal pattern. Symptoms often begin with burning, tingling, or localized pain, followed by a red rash that develops into fluid-filled blisters.

The rash typically resolves in 2–4 weeks, but some people, especially older adults, may develop postherpetic neuralgia—persistent nerve pain lasting weeks to months. Risk increases with age or immune suppression. Antiviral medications (e.g., valacyclovir, acyclovir) started early can reduce symptom severity and duration. Shingrix, a recombinant zoster vaccine, is recommended for adults over 50 to reduce the risk of shingles and its complications.

AI Summary of Treatment Experiences

Not medical advice.

# Herpes Zoster Treatment Summary Antivirals (valacyclovir, acyclovir, and famciclovir) form the cornerstone of acute treatment, with valacyclovir preferred due to convenient dosing and effectiveness when started within 72 hours of rash onset. All three antivirals effectively reduce rash duration and postherpetic neuralgia risk, though acyclovir requires more frequent dosing. Corticosteroids like prednisone may provide short-term pain relief and faster healing when combined with antivirals but don't prevent long-term complications and carry potential side effects. Shingrix vaccine is highly effective for prevention in adults 50+, reducing herpes zoster and postherpetic neuralgia risk by over 90% with a strong safety profile.