Prucalopride
Alternative Names: Motegrity
Prucalopride (Motegrity) is a prescription medication used to treat chronic idiopathic constipation, particularly in patients who have not responded to standard laxatives. It works as a selective serotonin 5-HT₄ receptor agonist, stimulating colonic motility and promoting more regular bowel movements. Prucalopride targets gut motility rather than stool consistency, making it useful for slow-transit constipation. It is generally well tolerated, with common side effects including headache, nausea, abdominal pain, and diarrhea, especially when starting therapy.
Treatment Type: Prescription Medication
Treatment Class: Serotonin agonist
Treatment Modality: Oral
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