Desmopressin

Other names: DDAVP

Categories: Prescription Medication

Description:

Desmopressin is a synthetic hormone used to treat certain types of von Willebrand disease (VWD). For patients with type 1 VWD and some with type 2 VWD, desmopressin is the first-line treatment. It works by stimulating the release of stored von Willebrand factor (VWF) and factor VIII (FVIII) from endothelial cells. Desmopressin can be given as an intravenous (IV) infusion, subcutaneous injection, or nasal spray. A desmopressin challenge test is recommended beforehand to assess the patient’s response and ensure it will be effective.

Treatment For:

von Willebrand disease

AI generated Summary: Based on the single expert review provided, Desmopressin appears to be an effective first-line treatment for type 1 and some type 2 cases of von Willebrand disease, if the patient responds to the medication. The review suggests that intravenous administration is the most reliable, followed by subcutaneous injection, while nasal spray has more variable absorption.

Reviews

Average rating: 4/5

Other Medical Provider ( 1 )

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Average rating: 5/5

Physician ( 1 )

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Average rating: 4.50/5

Total Reviews: 2

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

April 9, 2025

5.0

Desmopressin is first-line therapy for type 1 VWD and some type 2 cases, if the patient is responsive. It requires refrigeration, and among administration routes, IV is most reliable, followed by subcutaneous injection and then nasal spray, which has more variable absorption.

Wsprice

April 25, 2025

4.0

Desmopressin (DDAVP) works by releasing von Willebrand factor stored in cells near blood vessels, but its effect may be limited if cellular stores are low. Availability has been limited since a 2020 recall, though production is improving through partnerships like HFA and STAQ Pharma, with FDA clearance in 48 states. Insurance coverage remains slow to expand.

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