Von Willebrand disease (VWD) is the most common inherited bleeding disorder, caused by a deficiency or dysfunction of von Willebrand factor (VWF), a protein that helps blood clot. It affects both men and women and can lead to symptoms like easy bruising, frequent nosebleeds, heavy menstrual bleeding, and prolonged bleeding after injury or surgery.

There are three main types: Type 1 (mild, partial deficiency), Type 2 (moderate, abnormal function), and Type 3 (severe, almost no VWF). Diagnosis involves blood tests that measure VWF levels and function.

Treatment depends on the type and severity and may include desmopressin (to release stored VWF), VWF replacement therapy, or antifibrinolytics. Most people with VWD can manage the condition with proper medical care and precautions.