Clobetasol propionate 0.05%, also known by the brand name Temovate, is a super-potent prescription topical steroid used to treat plaque psoriasis. It is one of the strongest topical steroids available and can be very effective for thick, inflamed plaques on areas such as the elbows, knees, hands, feet, or scalp. Clobetasol works by quickly reducing inflammation, redness, itching, and scaling. Because it is very strong, it is usually used for short periods or in limited areas rather than as a long-term daily treatment. It is generally not the first choice for sensitive areas such as the face, groin, genitals, armpits, or skin folds because it can cause skin thinning, stretch marks, visible blood vessels, or irritation. When used carefully under clinician guidance, clobetasol can be a powerful option for psoriasis flares or stubborn plaques.