Roflumilast cream 0.3%, sold under the brand name Zoryve, is a non-steroid prescription cream used to treat plaque psoriasis. It works by blocking an enzyme called PDE-4, which helps reduce inflammation in the skin. Roflumilast may be especially helpful because it can be used on both regular plaque areas and sensitive areas such as the face, groin, genitals, armpits, and skin folds. Unlike topical steroids, it does not cause skin thinning, making it a useful option for longer-term or sensitive-area treatment. Many people find it convenient because it is typically applied once daily. Possible side effects include application-site irritation, diarrhea, headache, nausea, or trouble sleeping, although many people tolerate it well.