Piperacillin-tazobactam (Zosyn) is a broad-spectrum β-lactam/β-lactamase inhibitor that covers gram-positive, gram-negative, and anaerobic organisms. It is often used for hospitalized patients with severe aspiration pneumonia, particularly when there is concern for resistant organisms or complications such as abscess, empyema, or necrotizing infection. Unlike fluoroquinolones, Zosyn provides reliable anaerobic coverage, making it a strong choice in high-risk or complicated cases. However, it is typically reserved for moderate to severe disease in the inpatient setting, as narrower-spectrum agents are preferred for uncomplicated aspiration pneumonia to support antimicrobial stewardship.