Bazedoxifene

Categories: Prescription Medication

Description:

Bazedoxifene is a selective estrogen receptor modulator (SERM) combined with conjugated estrogens and is used as an alternative to traditional estrogen-progestin therapy for menopausal symptoms in women with a uterus. It provides relief from vasomotor symptoms and protects the endometrium without the need for added progestin, making it suitable for women who cannot tolerate progestogens. This combination is typically considered a second-line option for women seeking non-progestin hormonal therapy. Common side effects include muscle spasms, nausea, and abdominal pain; there is also a potential increased risk of venous thromboembolism. It is not recommended for women with a history of thromboembolic disease or estrogen-sensitive cancers.

Treatment For:

Menopause

AI generated Summary: Based on the single review provided by Dr. Curbside, Bazedoxifene combined with conjugated estrogens appears to be an effective treatment for menopausal symptoms, particularly for women with a uterus who cannot tolerate progestins. However, it carries a risk of blood clots and is contraindicated in women with a history of certain conditions such as venous thromboembolism, stroke, or estrogen-sensitive cancers.

Reviews

Average rating: 4/5

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Average rating: 4.00/5

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

May 25, 2025

4.0

Bazedoxifene combined with conjugated estrogens is a non-progestin option for treating menopausal symptoms in women with a uterus, offering relief from hot flashes while protecting the endometrium. It is a useful alternative for those who cannot tolerate progestins, but carries a risk of blood clots. It is contraindicated in women with a history of venous thromboembolism, stroke, or estrogen-sensitive cancers.

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