Alphanate

Categories: Prescription Medication

Description:

Alphanate is a plasma-derived concentrate that contains both von Willebrand factor (VWF) and factor VIII (FVIII), used to treat and prevent bleeding in patients with von Willebrand disease (VWD) and hemophilia A. It has a lower VWF:FVIII ratio (~0.5–0.7:1) compared to other products, meaning it provides more FVIII relative to VWF.

Alphanate is given by intravenous infusion and is appropriate for patients with VWD who are unresponsive to desmopressin, especially during surgery, trauma, or serious bleeding episodes. Due to its lower VWF content, it may be less optimal when high VWF levels are needed, and higher doses might be required in such cases. However, it remains a useful option in managing VWD when both clotting factors are needed.

Treatment For:

von Willebrand disease

AI generated Summary: Based on the provided information, there is only one review for the treatment 'Alphanate' against 'von Willebrand disease', and the reviewer "ER Doc" did not provide any content or rating. Due to the lack of sufficient data and user feedback, it is not possible to determine the effectiveness of this treatment for the given disease.

Reviews

Average rating: 3/5

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Average rating: 3.00/5

Total Reviews: 1

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

April 23, 2025

3.0

Alphanate is used less frequently for von Willebrand disease compared to products like Humate-P or Wilate because it has lower and more variable VWF activity, and its VWF:FVIII ratio is generally lower. This means it may require higher dosing or closer monitoring to achieve adequate VWF levels. Additionally, it is not FDA-approved specifically for VWD in the U.S. (only for hemophilia A with VWF activity as a secondary indication), which limits its preferred use in clinical guidelines.

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