Pramoxine is a topical anti-itch medication that can help relieve the itching associated with eczema. It works by temporarily numbing the skin’s nerve endings, which reduces the sensation of itching without using steroids. Pramoxine is often found in over-the-counter creams and lotions and can be helpful for short-term symptom relief, especially when itching is interfering with sleep or daily activities. It does not treat the underlying inflammation of eczema, so it is usually used alongside moisturizers or other treatments such as topical steroids. Most people tolerate it well, though it should be applied only to intact skin and used as directed.