Tranexamic acid (TXA) is an antifibrinolytic medication that helps stop nosebleeds by stabilizing clots and preventing them from breaking down. For epistaxis, it is most often applied topically, either on a cotton pledget or as a spray, and has been shown to control bleeding faster than traditional anterior packing. Studies suggest it can also reduce the chance of rebleeding, especially in patients taking blood thinners or antiplatelet medications. It is generally safe when used locally, with fewer side effects and better comfort compared to nasal packing.