Spironolactone

Other names: Aldactone

Categories: Prescription Medication

Description:

Spironolactone is a potassium-sparing diuretic and aldosterone antagonist used as an add-on therapy for heart failure with reduced ejection fraction (HFrEF), particularly in patients with persistent symptoms (NYHA class II–IV) despite standard treatment. It works by blocking aldosterone, which helps reduce sodium and water retention, prevent cardiac remodeling, and improve survival. Spironolactone has been shown to lower mortality and hospital.

Treatment For:

Congestive Heart Failure

AI generated Summary: Based on the single expert review provided, Spironolactone appears to be an effective treatment for congestive heart failure with reduced ejection fraction (HFrEF), particularly when used in combination with ACE inhibitors and beta blockers. The review suggests that Spironolactone has been shown to reduce mortality and hospitalization rates, making it a valuable addition to the standard treatment regimen for HFrEF patients with persistent symptoms.

Reviews

Average rating: 5/5

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

May 25, 2025

5.0

Spironolactone is a potassium-sparing diuretic commonly used for heart failure with reduced ejection fraction (HFrEF), particularly in patients with persistent symptoms despite ACE inhibitors and beta blockers. It has been shown to reduce mortality and hospitalization, but requires monitoring for hyperkalemia and renal function. It is generally low-cost, with generic versions widely available.

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