Other names: Entresto
Categories: Prescription Medication
Description:
Sacubitril/valsartan (Entresto) is a first-line medication for heart failure with reduced ejection fraction (HFrEF). It combines sacubitril, a neprilysin inhibitor that enhances beneficial vasodilatory peptides, with valsartan, an angiotensin receptor blocker (ARB) that reduces blood pressure and cardiac workload. This combination has been shown to significantly reduce cardiovascular death and heart failure hospitalizations compared to ACE inhibitors.
It is typically prescribed for patients with NYHA class II–IV symptoms, often in place of an ACE inhibitor or ARB, after ensuring no history of angioedema. Side effects may include hypotension, hyperkalemia, and renal dysfunction, so close monitoring is required during treatment.
Treatment For:
AI generated Summary: Based on the single expert review provided, Sacubitril/Valsartan appears to be a highly effective first-line treatment for congestive heart failure with reduced ejection fraction. The reviewer, Dr. Curbside, rates the treatment 5 out of 5, stating that it improves survival and reduces hospitalizations compared to ACE inhibitors, although it requires monitoring for potential side effects such as hypotension, kidney function, and potassium levels.
Sacubitril/Valsartan is a first-line therapy for heart failure with reduced ejection fraction, offering improved survival and reduced hospitalizations compared to ACE inhibitors. It is generally well tolerated but requires monitoring for hypotension, kidney function, and potassium levels.
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