Promethazine with codeine

Categories: Prescription Medication

Description:

Promethazine with codeine is a prescription cough syrup sometimes used for severe, disruptive cough. Promethazine is an antihistamine with sedative properties, while codeine is an opioid that suppresses the cough reflex. This combination may provide nighttime relief, especially when other treatments fail. However, due to risks of sedation, respiratory depression, and dependence, it’s generally not recommended as a first-line therapy and should be used with caution and only for short durations. It is contraindicated in children under 12 and not advised for routine use in bronchitis.

Treatment For:

Cough

AI generated Summary: Based on the single review provided by Dr. Curbside, the effectiveness of Promethazine with codeine for treating cough is questionable. The review suggests that studies have shown codeine to be no more effective than placebo in reducing cough associated with acute upper respiratory tract infections, and there are concerns about the potential for substance abuse due to its narcotic properties.

Reviews

Average rating: 3/5

Physician ( 1 )

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Average rating: 3.00/5

Total Reviews: 1

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

May 12, 2025

3.0

Some patients strongly believe that promethazine with codeine is the only thing that truly helps their cough. While I acknowledge it can be effective for severe symptoms, I’m generally reluctant to prescribe it due to the risk of opioid dependence, sedation, and respiratory depression. I reserve it for select cases where other treatments have failed and the benefit clearly outweighs the risk.

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