Description:
Probenecid is a uricosuric medication used for the long-term management of gout by increasing the excretion of uric acid through the kidneys. It is typically prescribed for patients who under-excrete uric acid and cannot tolerate or do not respond to xanthine oxidase inhibitors like allopurinol. Probenecid is not used during acute gout attacks and should be avoided in patients with significant kidney impairment. It also increases the risk of kidney stones, so patients are advised to stay well-hydrated and may require urine alkalinization.
Treatment For:
AI generated Summary: Based on the single review provided, Probenicid appears to be an effective second-line treatment for lowering uric acid levels in patients with gout who are under-excreters of uric acid. It is mainly used when first-line therapies, such as xanthine oxidase inhibitors (e.g., allopurinol or febuxostat), are contraindicated or not well-tolerated by the patient.
Probenecid is effective for lowering uric acid in under-excreters but is considered a second-line agent after xanthine oxidase inhibitors like allopurinol or febuxostat. It's mainly used when first-line therapies are contraindicated or not tolerated.
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