Pregabalin (brand name Lyrica) is an FDA-approved medication for managing fibromyalgia, particularly effective in reducing pain and improving sleep quality. It works by modulating nerve signals in the central nervous system, thereby decreasing pain perception. Clinical studies have demonstrated that a daily dose of 450 mg can significantly alleviate pain, enhance sleep, and reduce fatigue compared to placebo .

Common side effects include dizziness, drowsiness, weight gain, dry mouth, and blurred vision . While pregabalin is generally well-tolerated, some individuals may experience side effects that lead to discontinuation of the medication.