Pegloticase

Other names: KRYSTEXXA

Description:

Pegloticase is an intravenous biologic medication used for severe, treatment-refractory chronic gout. It works by converting uric acid into allantoin, a more soluble compound easily excreted by the kidneys. Pegloticase is typically reserved for patients who have failed or cannot tolerate conventional therapies like allopurinol or febuxostat. It is highly effective in rapidly lowering serum uric acid levels and resolving tophi, but carries risks including infusion reactions and development of anti-drug antibodies. Patients are usually pre-medicated and monitored closely during treatment.

Treatment For:

Gout

AI generated Summary: Based on the single review provided, Pegloticase appears to be a highly effective treatment for chronic, refractory gout when other standard therapies have failed. However, it can cause serious side effects, requires close monitoring, and is expensive, which may limit its accessibility for some patients.

Reviews

Average rating: 3/5

Physician ( 1 )

5

0
4

0
3

1
2

0
1

0

Average rating: 3.00/5

Total Reviews: 1

5

0
4

0
3

1
2

0
1

0

All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

May 25, 2025

3.0

Pegloticase is a third-line treatment for chronic, refractory gout, used when standard urate-lowering therapies like allopurinol or febuxostat fail or are not tolerated. It is highly effective but can cause serious side effects such as infusion reactions and anaphylaxis, requiring close monitoring and premedication. The treatment is expensive, with costs exceeding $30,000 per month, though financial assistance programs may help offset the price for eligible patients.

Write a Review

Comments: *

Disclaimer

The information, including but not limited to, text, graphics, images and other material contained on this website/app are for informational purposes only. No material on this site/app is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website/app.

Find the Best Treatments for Your Condition