Midodrine is a medication that raises blood pressure by tightening blood vessels, and it’s sometimes used in Long COVID for people with dysautonomia or POTS-like symptoms (such as dizziness, rapid heartbeat, or fainting when standing). By improving blood flow to the brain, it can help reduce lightheadedness and fatigue related to low blood pressure on standing. It’s usually considered when lifestyle changes, fluids, and salt intake aren’t enough to control symptoms. Side effects may include high blood pressure when lying down, tingling, or scalp itching, so careful monitoring is important. Midodrine does not treat the underlying cause of Long COVID but can ease specific autonomic symptoms and improve daily functioning.