Categories: Prescription Medication
Description:
Leuprolide is a widely used GnRH agonist for unfavorable intermediate-risk prostate cancer because it provides reliable and sustained testosterone suppression, which enhances the effectiveness of radiation therapy. It is supported by decades of clinical data and is included in major guidelines (e.g., NCCN, AUA) as a standard ADT (Androgen Deprivation Therapy) agent.
Leuprolide is commonly chosen due to its flexible dosing schedules (monthly, 3-, 4-, or 6-month depot injections), broad insurance coverage, and ease of administration in both urology and oncology practices. While it initially causes a temporary testosterone surge ("flare"), this can be managed with short-term anti-androgens. It remains a first-line ADT option because of its balance of efficacy, clinical familiarity, and logistical convenience.
Treatment For:
AI generated Summary: Based on the single review provided by Dr. Curbside, Leuprolide appears to be a highly effective and preferred treatment option for unfavorable intermediate risk prostate cancer when administered alongside radiation therapy for 4-6 months. However, it is important to note that the treatment can cause side effects such as hot flashes, fatigue, loss of libido, and metabolic changes.
Leuprolide is a preferred ADT option due to its proven effectiveness, widespread availability, and multiple dosing schedules (e.g., monthly, every 3, 4, or 6 months). It is usually administered for 4–6 months alongside radiation in this setting, and while effective, it can cause side effects like hot flashes, fatigue, loss of libido, and metabolic changes.
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