Intubation may be required in acute hereditary angioedema (HAE) attacks when airway swelling involves the tongue, throat, or larynx, making it difficult to breathe. Because HAE swelling can progress rapidly and unpredictably, early airway management is critical—intubation should be performed before complete obstruction develops. These cases can be challenging due to distorted anatomy, so experienced providers and advanced airway tools (such as a fiberoptic or video laryngoscope) are recommended. If intubation cannot be performed safely, an emergency surgical airway (such as a cricothyrotomy or tracheostomy) may be necessary. The main goal is early recognition and airway protection to prevent respiratory failure or death.