Intravenous Valproate Sodium

Other names: Depakote

Categories: Prescription Medication

Description:

IV Depakote (valproate sodium) is used for the acute treatment of migraines, particularly in emergency settings or for status migrainosus (severe, prolonged migraines). It works by enhancing GABA activity, stabilizing neuronal excitability, and reducing neurogenic inflammation.

while the effectiveness of IV valproate for acute migraine treatment is supported by some studies, it may be less effective compared to other treatments like metoclopramide and ketorolac. The recommended dosages range from 300 mg to 1200 mg, typically administered over 15-60 minutes.

Treatment For:

Migraine headache

AI generated Summary: Based on the single review provided by Dr. Curbside, Intravenous Valproate Sodium (IV Depakote) appears to be an effective treatment for migraine headaches, particularly in hospital and emergency settings. The reviewer highlights its usefulness for patients who cannot tolerate triptans or have contraindications to vasoconstrictive therapies, and notes its efficacy and relatively low side effect profile.

Reviews

Average rating: 4/5

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Average rating: 4.00/5

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

February 20, 2025

4.0

As a resident, I had a neurologist who preferred IV Depakote for migraines and would bolus 1 gram over 15 minutes.Though not a first-line option in all settings, IV Depakote can be particularly useful in patients who cannot tolerate triptans or have contraindications to vasoconstrictive therapies. Given its efficacy and relatively low side effect profile, it remains a valuable tool in migraine management, particularly in hospital and emergency settings.

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