Intravenous Valproate Sodium

Other names: Depakote

Categories: Prescription Medication

Description:

IV Depakote (valproate sodium) is used for the acute treatment of migraines, particularly in emergency settings or for status migrainosus (severe, prolonged migraines). It works by enhancing GABA activity, stabilizing neuronal excitability, and reducing neurogenic inflammation.

while the effectiveness of IV valproate for acute migraine treatment is supported by some studies, it may be less effective compared to other treatments like metoclopramide and ketorolac. The recommended dosages range from 300 mg to 1200 mg, typically administered over 15-60 minutes.

Treatment For:

Migraine headache

AI generated Summary: Based on the provided information, there are no user reviews available for the treatment "Intravenous Valproate Sodium" against "Migraine headache." However, the author review suggests that this treatment can be effective, especially for patients who cannot tolerate triptans or have contraindications to vasoconstrictive therapies. The author rates the treatment as 4 out of 5, indicating that it is a valuable option for managing migraines in hospital and emergency settings, with relatively low side effects.

Reviews

Average rating: 4/5

Medical Physician ( 1 )

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Total Reviews: 1

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All Non medical Medical physician Other medical provider

JAFERD+

February 20, 2025

4.0

As a resident, I had a neurologist who preferred IV Depakote for migraines and would bolus 1 gram over 15 minutes.

Though not a first-line option in all settings, IV Depakote can be particularly useful in patients who cannot tolerate triptans or have contraindications to vasoconstrictive therapies. Given its efficacy and relatively low side effect profile, it remains a valuable tool in migraine management, particularly in hospital and emergency settings.

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