Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve fever, headache, sore throat, body aches, and sinus pain associated with the common cold and other upper respiratory infections. It works by reducing inflammation and lowering prostaglandin production, which helps decrease pain and fever. Ibuprofen does not treat the underlying viral infection, but it can significantly improve comfort while the illness runs its course. It is available over the counter in various doses and formulations and may be taken alone or as part of combination cold medications. As with all NSAIDs, it should be used as directed and avoided or used cautiously in individuals with kidney disease, stomach ulcers, or certain cardiovascular conditions.