Gabapentin (Neurontin) is an anticonvulsant and nerve pain medication sometimes used off-label to treat persistent or intractable hiccups, especially when they have a neurological origin or are resistant to other treatments. It works by modulating calcium channels in the nervous system, helping to regulate nerve signaling involved in hiccups. By reducing excessive nerve excitability, it calms involuntary diaphragm spasms. Additionally, its sedative effects may help relax the muscles associated with the hiccup reflex. This makes gabapentin a potential alternative for patients who do not respond to traditional hiccup treatments.