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Estrogen and Progestin

Categories: Prescription Medication

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Description:

Estrogen and progestin, commonly delivered through combined oral contraceptives (COCs), are an effective hormonal treatment for moderate to severe acne in women, especially when linked to hormonal fluctuations. They work by reducing androgen levels, which in turn decreases sebum production and helps prevent clogged pores. 

COCs are typically considered a second-line therapy after topical treatments and may be combined with other systemic or topical agents. Common side effects include nausea, breast tenderness, mood changes, and an increased risk of blood clots, especially in smokers or women over 35. It may take several months to see full benefits, but they are particularly useful for women with persistent or hormonally driven acne.

Treatment For:

AI generated Summary: Based on the single expert review, estrogen and progestin (combined oral contraceptives) can be an effective treatment for moderate to severe or hormonally driven acne in women, particularly when topical treatments are insufficient or acne flares with menstrual cycles. However, the treatment carries risks such as blood clots, stroke, and hypertension, especially in smokers or women over 35, and should be used with caution in those with cardiovascular risk factors.

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Dr. Curbside

  • May 25, 2025

4.0

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