Clonidine is a blood pressure medication (an alpha-2 adrenergic agonist) that is often used off-label to help manage the symptoms of opioid withdrawal. It does not act on opioid receptors, but instead reduces excessive activity in the nervous system, easing anxiety, sweating, agitation, runny nose, and rapid heartbeat. Unlike methadone or buprenorphine, clonidine does not relieve cravings or fully prevent withdrawal, but it can make the process more tolerable. It is typically used in short-term detox settings or when opioid-based treatments are not available or appropriate. Careful monitoring is needed, since clonidine can cause low blood pressure, dizziness, or sedation.