Clindamycin is a topical or oral antibiotic used to treat bacterial folliculitis, particularly when caused by Staphylococcus aureus or Streptococcus species. It is often prescribed in topical form (as a lotion, gel, or solution) for mild to moderate localized cases, especially when other treatments like benzoyl peroxide or mupirocin aren’t sufficient. Oral clindamycin may be used for more extensive or resistant infections, including those suspected to involve MRSA, depending on local resistance patterns.

Clindamycin works by inhibiting bacterial protein synthesis and also has anti-inflammatory properties, which can help reduce swelling and irritation. When used topically, it’s often combined with benzoyl peroxide to minimize bacterial resistance. Side effects may include skin dryness or irritation topically, and diarrhea or risk of C. difficile colitis when taken orally. It’s generally considered second-line or adjunctive therapy in most cases, especially when broader-spectrum or MRSA coverage is needed.