Ceftriaxone is the first-line antibiotic treatment for gonorrhea due to its strong activity against Neisseria gonorrhoeae. It is a third-generation cephalosporin given as a single intramuscular injection (typically 500 mg for most adults; 1 g if ≥150 kg). Ceftriaxone works by inhibiting bacterial cell wall synthesis, leading to rapid bacterial death. Because gonorrhea has developed resistance to many other antibiotics, ceftriaxone remains the cornerstone of therapy, often paired with testing for and treatment of coexisting infections such as chlamydia. It is generally well tolerated, though some patients may experience mild pain at the injection site or rare allergic reactions.