Ceftriaxone is a third-generation cephalosporin antibiotic used primarily for acute bacterial prostatitis, especially in hospitalized patients or when a severe infection is suspected. It works by inhibiting bacterial cell wall synthesis, leading to cell death, and is effective against many gram-negative organisms such as E. coli and Klebsiella, as well as some gram-positive bacteria. Ceftriaxone is given by intravenous or intramuscular injection, making it suitable for patients unable to tolerate oral therapy or with systemic symptoms like fever or sepsis. It is often used initially, then switched to an oral agent such as ciprofloxacin or trimethoprim-sulfamethoxazole once the patient improves.