Amoxicillin-clavulanate is sometimes used to treat urinary tract infections, particularly when the bacteria are known or suspected to be resistant to simpler antibiotics. It combines amoxicillin with clavulanate, which helps overcome bacterial resistance and broadens its activity against organisms such as E. coli, Klebsiella, and Proteus species. While effective, Augmentin is usually not the first-line treatment for uncomplicated UTIs because other antibiotics tend to work better and cause fewer gastrointestinal side effects. It is more commonly used when culture results guide therapy or when other options are not appropriate. Taking it with food can help reduce stomach upset and diarrhea.