Prilosec (omeprazole) is a medication that reduces stomach acid and is commonly used in eosinophilic esophagitis (EoE), especially when reflux or irritation may be contributing to symptoms. Some people report improvement in swallowing, heartburn, chest discomfort, or food sticking, although it may not fully address the underlying inflammatory component of EoE in everyone. It can also help people who have overlapping gastritis or acid reflux symptoms. One advantage is that it is available over the counter and relatively inexpensive, although some people use higher or prescription-strength dosing under medical guidance.