Amoxicillin-clavulanate (Augmentin) can be used for bacterial prostatitis when the infection is caused by susceptible organisms, particularly Enterococcus or Streptococcus species. It works by inhibiting bacterial cell wall synthesis while the clavulanate component blocks beta-lactamase enzymes, extending its spectrum. However, it is less effective against many gram-negative bacteria and has limited prostate penetration, so it is generally not a first-line choice. It may be considered in mild cases, or when culture results confirm sensitivity. Common side effects include gastrointestinal upset and diarrhea.