Pyridostigmine is a medication that improves communication between nerves and muscles, and it’s sometimes used for conditions like myasthenia gravis. In Long COVID, it may be considered for people with dysautonomia or POTS-like symptoms, such as dizziness, rapid heart rate, or exercise intolerance. By enhancing nerve signaling, it can help regulate heart rate and blood pressure, improving tolerance for standing and daily activities. Side effects can include stomach upset, diarrhea, or muscle cramps, so dosing must be carefully adjusted. While not a cure for Long COVID, pyridostigmine can be a supportive option for managing autonomic symptoms in select patients.