Mechanical thrombectomy is a highly effective treatment for acute ischemic stroke caused by large-vessel occlusion. It uses specialized catheters and devices, such as stent retrievers or aspiration systems, to physically remove the clot and restore blood flow. The procedure works best within 6 hours of symptom onset but can be beneficial up to 24 hours in carefully selected patients. It is often combined with IV thrombolysis when appropriate, further improving outcomes. Because it requires a specialized stroke center with trained interventionalists, it is not available at all hospitals, and patients may need transfer to a comprehensive stroke facility.