Memantine and Donepezil

Other names: Namzaric

Categories: Prescription Medication

Description:

Memantine + donepezil (Namzaric®) is a combination medication used for moderate to severe Alzheimer’s disease. It combines memantine, which regulates glutamate activity to protect brain cells, with donepezil, which boosts acetylcholine to support memory and thinking. Together, they may provide broader benefits in cognition, behavior, and daily functioning compared to either drug alone. The medication is taken once daily as an oral capsule. Side effects can include dizziness, headache, diarrhea, or loss of appetite, but it is generally well tolerated.

Treatment For:

Alzheimer’s disease

AI generated Summary: Based on the provided information, there are no user reviews or ratings available for the treatment 'Memantine and Donepezil' against Alzheimer's disease. The author has not provided a review or rating either. Therefore, it is not possible to determine the effectiveness of this treatment for Alzheimer's disease without further data or evidence.

Reviews

Average rating: 5/5

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

September 30, 2025

5.0

Using donepezil and memantine in combination provides greater benefit than either drug alone for patients with moderate to severe Alzheimer’s disease. Studies show the combination can lead to slower decline in cognition, daily functioning, and behavior, offering improved overall clinical outcomes compared to monotherapy. The complementary mechanisms—donepezil enhancing cholinergic signaling and memantine reducing glutamate-related excitotoxicity—work together to provide broader symptom control.

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