Gentamicin plus azithromycin

Categories: Prescription Medication

Description:

Gentamicin 240 mg intramuscularly plus azithromycin 2 g orally as a single dose is an alternative regimen for the treatment of gonorrhea. It is generally considered when ceftriaxone is not available or cannot be used (for example, due to severe allergy). Clinical trials have shown this combination to be effective against Neisseria gonorrhoeae, though slightly less reliable than ceftriaxone, especially at pharyngeal sites. Gentamicin disrupts bacterial protein synthesis, while azithromycin blocks ribosomal function, giving a dual mechanism to help overcome resistance. Side effects may include gastrointestinal upset from high-dose azithromycin and injection-site pain from gentamicin.

Treatment For:

Gonorrhea

AI generated Summary: Based on the provided information, there are no user reviews available for the treatment 'Gentamicin 240 mg intramuscularly plus azithromycin 2 g orally' against the disease 'Gonorrhea'. The author of the article has not provided a review or rating for this treatment. Therefore, there is insufficient data to determine the effectiveness of this treatment for Gonorrhea based on the given information.

Reviews

Average rating: 4/5

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

September 8, 2025

4.0

Gentamicin plus azithromycin is an alternative regimen for gonorrhea, reserved for situations where ceftriaxone cannot be used, such as severe allergy. While it can be effective, especially for urogenital infections, it has lower efficacy than ceftriaxone and is less reliable for pharyngeal disease. Because of these limitations and higher rates of gastrointestinal side effects from high-dose azithromycin, it is not a first-line option and should only be used when ceftriaxone is contraindicated.

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