Alprostadil

Other names: Caverject, Edex, MUSE

Categories: Prescription Medication

Description:

Alprostadil is a non–PDE-5 inhibitor option for treating erectile dysfunction (ED). It is a synthetic version of prostaglandin E1, which works by relaxing smooth muscle and dilating blood vessels in the penis to increase blood flow. Unlike oral medications, alprostadil is given either as a penile injection (Caverject, Edex) or as a urethral suppository (MUSE). Its onset is rapid—usually within 5–20 minutes—and it doesn’t require sexual stimulation to be effective. Common side effects include penile pain, prolonged erection (priapism), and local irritation; with injections, there is also a small risk of bleeding or scar tissue formation at the injection site.

Treatment For:

Erectile Dysfunction

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Average rating: 4/5

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

August 26, 2025

4.0

Alprostadil is a prostaglandin E1 therapy for erectile dysfunction, available as an injection (Caverject, Edex) or urethral suppository (MUSE). It produces erections independent of sexual stimulation and is often prescribed when oral PDE-5 inhibitors are ineffective or contraindicated. It can be very effective, but penile pain and the invasive delivery methods may limit its use.

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