Metoprolol succinate

Other names: Toprol-XL

Categories: Prescription Medication

Description:

Metoprolol succinate (extended-release) is a beta-blocker commonly used as a first-line therapy for heart failure with reduced ejection fraction (HFrEF). It works by slowing the heart rate and reducing the heart’s workload, which helps improve heart function over time and reduces the risk of hospitalization and death.

Only the succinate (extended-release) form is approved for CHF—not metoprolol tartrate. It is typically started at a low dose and gradually increased as tolerated. Common side effects include fatigue, bradycardia (slow heart rate), and low blood pressure, especially during dose titration. Despite initial fatigue, long-term use improves symptoms, ejection fraction, and survival in stable CHF patients.

Treatment For:

Congestive Heart Failure

AI generated Summary: Metoprolol succinate is a highly effective first-line treatment for congestive heart failure with reduced ejection fraction (HFrEF). It has been shown to reduce mortality and hospitalizations, improve heart function over time, and is generally well-tolerated. As a low-cost generic drug, it is an accessible option for long-term management of HFrEF.

Reviews

Average rating: 5/5

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

May 25, 2025

5.0

Metoprolol succinate is a first-line, guideline-recommended beta-blocker for heart failure with reduced ejection fraction (HFrEF), shown to reduce mortality and hospitalizations. It is generally well tolerated, improves heart function over time, and is available as a low-cost generic, making it an accessible option for long-term management. Only the extended-release (succinate) form is used for CHF.

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