Milnacipran

Categories: Prescription Medication

Description:

Milnacipran is an FDA-approved, first-line treatment for fibromyalgia that targets both pain and fatigue. It is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by modulating pain signals in the central nervous system. Clinical trials have shown it improves physical function and reduces overall symptom severity.

Common side effects include nausea, headache, increased blood pressure, and insomnia. It is typically used when non-drug therapies or other medications like duloxetine or pregabalin are not fully effective.

Treatment For:

Fibromyalgia

AI generated Summary: Based on the single expert review provided, Milnacipran appears to be an effective first-line pharmacologic treatment for fibromyalgia, particularly in reducing pain and fatigue. As an SNRI approved specifically for fibromyalgia, it modulates pain processing in the central nervous system and may be more energizing than other SNRIs, making it a good option for patients with prominent fatigue but without major mood symptoms.

Reviews

Average rating: 5/5

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

May 25, 2025

5.0

Milnacipran is a first-line pharmacologic treatment for fibromyalgia, particularly effective in reducing pain and fatigue. As an SNRI, it modulates pain processing in the central nervous system and is typically used when non-drug therapies are insufficient. Approved specifically for fibromyalgia, milnacipran may be more energizing than other SNRIs, making it a good option for patients with prominent fatigue but without major mood symptoms.

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