Duloxetine

Categories: Prescription Medication

Description:

Duloxetine is an FDA-approved medication for the treatment of fibromyalgia, particularly effective in managing chronic pain, fatigue, and associated mood symptoms. It is a serotonin-norepinephrine reuptake inhibitor (SNRI) that helps modulate pain signaling in the central nervous system. Clinical studies have shown that duloxetine can reduce pain severity and improve physical function and quality of life. Common side effects include nausea, dry mouth, dizziness, and fatigue. It is often considered when non-pharmacologic treatments alone are insufficient.

Treatment For:

Fibromyalgia

AI generated Summary: Based on the single expert review provided, Duloxetine appears to be a highly effective first-line pharmacologic treatment for fibromyalgia, especially for patients experiencing both pain and mood symptoms. As a serotonin-norepinephrine reuptake inhibitor (SNRI), it helps reduce central pain sensitization and has been shown to improve function and quality of life in fibromyalgia patients when non-drug approaches are insufficient.

Reviews

Average rating: 5/5

Physician ( 2 )

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Average rating: 5.00/5

Total Reviews: 2

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

May 25, 2025

5.0

Duloxetine is a first-line pharmacologic treatment for fibromyalgia, particularly effective for patients with both pain and mood symptoms. As an SNRI, it helps reduce central pain sensitization and has shown benefit in improving function and quality of life. It’s commonly used when non-drug approaches like exercise or CBT are not enough.

ER9560

May 15, 2025

5.0

Duloxetine is a first-line SNRI for fibromyalgia, especially effective in patients with both pain and mood symptoms. It improves pain, function, and quality of life when non-drug treatments are insufficient. However, it carries a higher risk of side effects like nausea, fatigue, dry mouth, sexual dysfunction, and withdrawal symptoms if discontinued abruptly.

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