Valproate

Other names: Depakote

Categories: Prescription Medication

Description:

Depakote (divalproex sodium/valproate) is an FDA-approved medication for migraine prevention, primarily used in patients with frequent or severe migraines. It works by enhancing GABA activity, stabilizing neuronal excitability, and reducing neurogenic inflammation, which helps prevent migraine attacks.

Treatment For:

Migraine headache

AI generated Summary: Based on the provided information, there is only one review for the treatment 'Valproate' against 'Migraine headache', but the review does not contain any content or rating. Therefore, there is insufficient data to determine the effectiveness of this treatment for migraine headaches based on the given reviews and ratings.

Reviews

Average rating: 4/5

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Average rating: 4.00/5

Total Reviews: 1

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All Physician Healthcare provider (non-physician) Healthcare Consumer (Patients & Caregivers)

Dr. Curbside

May 22, 2025

4.0

IV Depakote (valproate) is used in the emergency setting for acute migraine relief, especially in patients who cannot tolerate oral medications or when nausea/vomiting is present. It often provides pain reduction within 30–60 minutes and is generally well tolerated. Oral valproate (divalproex sodium) is approved for migraine prevention, particularly effective in patients with frequent, severe migraines. It is typically reserved for those who do not respond to first-line preventive agents due to its side effect profile, which includes weight gain, fatigue, tremor, and teratogenicity.

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