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    Ondansetron

    Other names: Zofran

    Categories: Prescription Medication

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    Description:

    Zofran (Ondansetron) is a commonly prescribed medication to prevent and treat nausea and vomiting. It belongs to a class of drugs called 5-HT3 receptor antagonists, which work by blocking serotonin receptors in the brain and gut that can trigger the nausea reflex.


    How Zofran Works
    • Mechanism of Action: Zofran specifically targets serotonin, a neurotransmitter involved in triggering nausea and vomiting, by blocking its receptors in the chemoreceptor trigger zone (CTZ) of the brain and in the gastrointestinal tract. This helps to prevent nausea signals from being sent to the brain.

    Common Uses

    Zofran is particularly effective for nausea caused by:

    • Chemotherapy: Often given to patients undergoing chemotherapy to reduce nausea and vomiting associated with cancer treatments.
    • Radiation Therapy: Can help control nausea linked to radiation.
    • Postoperative Nausea: Used after surgery to manage nausea and vomiting from anesthesia.
    • Pregnancy (Hyperemesis Gravidarum): Sometimes prescribed off-label for severe morning sickness, although this should be done under careful supervision by a healthcare provider.

    Forms and Dosage
    • Tablets: Typically in doses of 4 mg and 8 mg, taken every 8 to 12 hours as needed.
    • Orally Disintegrating Tablets (ODT): Dissolve on the tongue for easier administration, especially helpful for those who cannot keep pills down.
    • Liquid Solution and Injectable Form: Used in hospitals for severe cases.

    Potential Side Effects

    While generally well-tolerated, Zofran can cause side effects, including:

    • Headache
    • Fatigue or drowsiness
    • Constipation or diarrhea
    • Rarely, it may cause QT prolongation, a heart rhythm condition, which can be serious. This risk is higher with higher doses or in people with pre-existing heart conditions.

    Treatment For:

    Nausea

    AI generated Summary: Based on the single review provided, Ondansetron appears to be highly effective in treating nausea, particularly during pregnancy. The reviewer rated the treatment 5 out of 5 and mentioned that it "works wonderfully." However, more reviews would be needed to draw a more comprehensive conclusion about the treatment's overall effectiveness.

    Reviews

    Average rating: 5/5
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    Average rating: 5.00/5
    Total Reviews: 2
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    Dr. Curbside

    • November 3, 2024

    5.0

    Nursekwis

    • November 5, 2024

    5.0

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