Zoliflodacin

Alternative Names: Nuzolvence

Zoliflodacin is a first-in-class oral antibiotic approved on December 12, 2025, for the treatment of uncomplicated gonorrhea. It is administered as a single oral dose and works by inhibiting bacterial DNA gyrase through a mechanism distinct from fluoroquinolones. Clinical trials demonstrated efficacy in treating urogenital infections, with lower effectiveness observed in pharyngeal infections. It provides an additional treatment option as antibiotic resistance in gonorrhea continues to evolve.

Treatment Type: Prescription Medication

Treatment Class: Other

Treatment Modality: Oral

Zoliflodacin

Review Summary

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Breakdown by Category

Each categories are rated on a 1–5 scale, with 5 being the most favorable outcome and 1 being the least. These scores are averaged across all user reviews to provide a clear sense of how this treatment typically performs in each area.

Cost
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1 = Very Expensive 5 = Very Affordable

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Very Expensive
Relief Speed
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1 = No Relief 5 = Immediate Relief

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No Relief
Side Effects
0
1 = Intolerable Effect 5 = No Effect

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Intolerable Effect
Treatment Line
0
1 = Third-line or more 5 = First-line

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Third-line or more

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Cost
Very Expensive
$1000+
Expensive
$501 to $1000
Moderate Cost
$101 to $500
Affordable
$25 to $100
Very Affordable
$25
Relief Speed
No Relief
No noticeable improvement
Slow Relief
Several days to weeks
Moderate Relief
Within 1 - 3 days
Fast Relief
Within hours
Immediate Relief
Within minutes
Side Effect
Intolerable Side Effect
Caused treatment to stop or required hospitalization
Severe Side Effect
Difficult to tolerate, may require intervention
Moderate Side Effect
Noticeable, but manageable
Mild Side Effect
Minor, not bothersome
No Side Effect
Without any adverse effects
Treatment Line
Third-line or more
Used after second-line failed or multiple prior treatment
Second-line
Used after first-line treatment failed or was unsuitable
First-line
First treatment tried

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